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Pyrogens act on the ________ of the brain where they cause release of ________.


A) hippocampus; PGE2
B) hippocampus; exudate
C) hypothalamus; PGE2
D) hypothalamus; exudate

E) B) and C)
F) All of the above

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Active immunity is a natural process, whereas passive immunity is generated artificially.

A) True
B) False

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Chemotaxis is the process by which


A) CAMs on leukocytes adhere to CAMs on endothelial cells of capillaries within injured tissues.
B) cells migrate along chemical gradients.
C) cells exit the blood by squeezing out between cells in the blood vessel wall.
D) chemical messengers are secreted that stimulate the sensation of pain that accompanies inflammation.

E) A) and D)
F) C) and D)

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When a chemical messenger has a short half-life, it means that


A) it will not have an extremely prolonged effect on target cells.
B) it will not be eliminated quickly from the blood.

C) A) and B)
D) undefined

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If a substance is not immunogenic by itself, but initiates an immune reaction when combined with a protein in the body, that substance is called a ________.

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Most bacterial species are pathogenic.

A) True
B) False

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Often a virus-infected cell will release ________ to prevent spread of the infection.


A) histamine
B) complement
C) interferon
D) perforin
E) serotonin

F) B) and C)
G) All of the above

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Plasma cells have a life span of about ________, which is mainly spent in the ________.


A) 5 days; blood
B) 5 days; lymph nodes
C) 130 days; blood
D) 130 days; lymph nodes

E) B) and D)
F) A) and B)

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Exudate is


A) blood that escapes capillaries, passes beyond the skin and leaves the body.
B) increased perfusion of capillary beds within the region of an injury.
C) lymph that flows away from the heart and toward the site of an injury.
D) fluid that leaves capillaries to "wash" the interstitial space of an injured tissue.
E) clotting proteins that wall off microbes and prevent them from spreading through the bloodstream.

F) C) and D)
G) A) and C)

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Sustained fevers that are 1°C above normal core body temperature usually lead to irreversible brain damage.

A) True
B) False

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One function of helper T-lymphocytes is to enhance the activity of cells of the innate immune system.

A) True
B) False

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In the classical pathway of complement activation,


A) complement is activated within liver cells and released into the blood.
B) complement binds to an antibody that is bound to a foreign substance.
C) complement binds with polysaccharides on a microbial cell wall.
D) complement inhibits inflammation and binds to opsonins.

E) A) and D)
F) None of the above

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Immunity can be transferred from mother to child. When the child's immunity is acquired


A) through the placenta, it is passive immunity, but through breastmilk it is active immunity.
B) through the placenta or through breastmilk, it is passive immunity.
C) through the placenta or through breastmilk, it is active immunity.
D) through the placenta, it is active immunity, but through the breastmilk it is passive immunity.

E) A) and C)
F) A) and D)

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Cytokines have a ________ half-life and exert influence on ________.


A) long; immune cells only
B) long; immune and non-immune cells
C) short; immune cells only
D) short; immune and non-immune cells

E) A) and B)
F) None of the above

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Interferons are one of the classes of


A) interleukins.
B) cytokines.
C) colony-stimulating factors.
D) tumor necrosis factors.

E) B) and D)
F) A) and D)

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Defensins and lysosomes are both part of ________ immunity and function as ________.


A) adaptive; physical barriers to pathogen entry
B) adaptive; attackers of pathogenic cells
C) innate; physical barriers to pathogen entry
D) innate; attackers of pathogenic cells

E) None of the above
F) B) and D)

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Antigens are


A) something made by a white blood cell to destroy a pathogen.
B) something that an antibody or T-lymphocyte binds to.
C) disorders involving overactive immune systems.
D) membrane receptors on B-lymphocytes.

E) B) and D)
F) A) and D)

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Active immunity requires


A) the transfer of antibodies from another individual.
B) direct encounter with the antigen.
C) that an active virus be used in a vaccine.
D) that all immune responses to the pathogen result in symptoms of illness.

E) A) and B)
F) B) and C)

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MHC class I molecules present peptide fragments that are either "self" or "nonself"; in either case, the fragment becomes bound to the molecule while


A) in the Golgi apparatus.
B) in the cytosol.
C) in a secretory vesicle.
D) in the rough endoplasmic reticulum.

E) All of the above
F) A) and D)

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Lymphocytes that are able to bind and respond to antigen are said to be ________.

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